The role of Rdl in resistance to phenylpyrazoles in Drosophila melanogaster

EJ Remnant; CJ Morton; PJ Daborn; C Lumb; YT Yang; HL Ng; MW Parker; P Batterham

Journal article

The role of Rdl in resistance to phenylpyrazoles in Drosophila melanogaster

EJ Remnant, CJ Morton, PJ Daborn, C Lumb, YT Yang, HL Ng, MW Parker, P Batterham

Insect Biochemistry and Molecular Biology | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2014

DOI: 10.1016/j.ibmb.2014.08.008

Abstract

Extensive use of older generation insecticides may result in pre-existing cross-resistance to new chemical classes acting at the same target site. Phenylpyrazole insecticides block inhibitory neurotransmission in insects via their action on ligand-gated chloride channels (LGCCs). Phenylpyrazoles are broad-spectrum insecticides widely used in agriculture and domestic pest control. So far, all identified cases of target site resistance to phenylpyrazoles are based on mutations in the Rdl (Resistance to dieldrin) LGCC subunit, the major target site for cyclodiene insecticides. We examined the role that mutations in Rdl have on phenylpyrazole resistance in Drosophila melanogaster, exploring natu..

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University of Melbourne Researchers

Craig Morton Author

Michael Parker Author

Philip Batterham Author

Related Projects (2)

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This research was supported by an Australian Research Council Linkage Grant (LP100100825) to P.B. and M.W.P. and funding from Novartis Animal Health Australasia P/L. SVI acknowledges infrastructure funding from the Victorian Government Operational Infrastructure Support Scheme. M.W.P. is a National Health and Medical Research Council of Australia Research Fellow.